TitleNatural variation in Caenorhabditis briggsae mitochondrial form and function suggests a novel model of organelle dynamics
Publication TypeJournal Article
Year of Publication2013
AuthorsHicks, KA, Denver, DR, Estes, S
Type of ArticleJournal Article

Mitochondrial functioning and morphology are known to be connected through cycles of organelle fusion and fission that depend upon the mitochondrial membrane potential (Delta Psi M); however, we lack an understanding of the features and dynamics of natural mitochondrial populations. Using data from our recent study of univariate mitochondrial phenotypic variation in Caenorhabditis briggsae nematodes, we analyzed patterns of phenotypic correlation for 24 mitochondrial traits. Our findings support a role for Delta Psi M in shaping mitochondrial dynamics, but no role for mitochondrial ROS. Further, our study suggests a novel model of mitochondrial population dynamics dependent upon cellular environmental context and with implications for mitochondrial genome integrity. (c) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

URL<Go to ISI>://WOS:000315757100006