TitleMolecular phylogeny of glutathione-S-transferases
Publication TypeJournal Article
Year of Publication1997
AuthorsSnyder, MJ, Maddison, DR
JournalDNA and Cell Biology
Volume16
Pagination1373-1384
Type of ArticleJournal Article
ISSN1044-5498
Abstract

The glutathione-S-transferase (GST) protein superfamily is currently composed of nearly 100 sequences, This study documents a greater phylogenetic diversity of GSTs than previously realized. Parsimony and distance phylogenetic methods of GST amino acid sequences yielded virtually the same results. There appear to be at least 25 groups (families) of GST-like proteins, as different from one another as are the currently recognized classes, This diversity will require the design of a new nomenclature for this large protein superfamily. There is one well-supported large clade containing the mammalian mu, pi, and alpha classes as well as GSTs from molluscs, helminths, nematodes, and arthropods.

URL<Go to ISI>://WOS:A1997YK48100012
DOI10.1089/dna.1997.16.1373