Title | Identification of mesotocin and vasotocin nucleotide sequences in two species of urodele amphibian |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Searcy, BT, Walthers, EA, Heppner, BL, Thompson, RR, Moore, FL |
Journal | General and Comparative Endocrinology |
Volume | 160 |
Pagination | 111-116 |
Type of Article | Journal Article |
ISSN | 0016-6480 |
Abstract | We amplified and identified, for the first time in urodele amphibians, cDNA sequences that encode preprovasotocin (preproVT) and prepromesotocin (preproMT) from two distinct urodelian species, Taricha granulosa (the rough-skinned newt) and Plethodon shermanii (the spotted salamander). Each of these cDNA sequences encoded proteins that contained the characteristics of known neurohypophysial peptide precursors; each Sequence consisting of (1) a signal peptide, (2) VT- or MT-like peptides, (3) neurophysin, and for the preproVTs, (4) copeptin. In T. granulosa, cDNA sequences encoded for the nine amino acids that define VT or MT. In A shermani, cDNA sequences encoded for the VT peptide and a previously unidentified isoform of MT, ([Val(4)]-MT). (C) 2008 Elsevier Inc. All rights reserved. |
URL | <Go to ISI>://WOS:000262777700001 |
DOI | 10.1016/j.ygcen.2008.11.013 |