TitleA CORTICOSTEROID RECEPTOR IN NEURONAL MEMBRANES
Publication TypeJournal Article
Year of Publication1991
AuthorsOrchinik, M, Murray, TF, Moore, FL
JournalScience
Volume252
Pagination1848-1851
Type of ArticleJournal Article
ISSN0036-8075
Abstract

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [H-3]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [H-3]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.

URL<Go to ISI>://WOS:A1991FU06100040
DOI10.1126/science.2063198