- Our Impact
|Title||A CORTICOSTEROID RECEPTOR IN NEURONAL MEMBRANES|
|Publication Type||Journal Article|
|Year of Publication||1991|
|Authors||Orchinik, M, Murray, TF, Moore, FL|
|Type of Article||Journal Article|
Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [H-3]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [H-3]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.
|URL||<Go to ISI>://WOS:A1991FU06100040|