TitleBehavioral, pharmacological, and molecular characterization of an amphibian cannabinoid receptor
Publication TypeJournal Article
Year of Publication2000
AuthorsSoderstrom, K, Leid, M, Moore, FL, Murray, TF
JournalJournal of Neurochemistry
Type of ArticleJournal Article

{Investigation of cannabinoid pharmacology in a vertebrate with a phylogenetic history distinct from that of mammals may allow better understanding of the physiological significance of cannabinoid neurochemistry. Taricha granulosa, the roughskin newt, was used here to characterize an amphibian cannabinoid receptor. Behavioral experiments demonstrated that the cannabinoid agonist levonantradol inhibits both newt spontaneous locomotor activity and courtship clasping behavior, Inhibition of clasping was dose-dependent and potent (IC50 = 1.2 mu g per animal). Radioligand binding studies using [H-3]CP-55940 allowed identification of a specific binding site (K-D = 6.5 nM

URL<Go to ISI>://WOS:000087659000048