TitleBayesian parentage analysis with systematic accountability of genotyping error, missing data and false matching
Publication TypeJournal Article
Year of Publication2013
AuthorsChristie, MR, Tennessen, JA, Blouin, M
JournalBioinformatics
Volume29
Pagination725-732
Type of ArticleJournal Article
ISSN1367-4803
Abstract

Motivation: The goal of any parentage analysis is to identify as many parent-offspring relationships as possible, while minimizing incorrect assignments. Existing methods can achieve these ends, but they require additional information in the form of demographic data, thousands of markers and/or estimates of genotyping error rates. For many non-model systems, it is simply not practical, cost-effective or logistically feasible to obtain this information. Here, we develop a Bayesian parentage method that only requires the sampled genotypes to account for genotyping error, missing data and false matches. Results: Extensive testing with microsatellite and SNP datasets reveals that our Bayesian parentage method reliably controls for the number of false assignments, irrespective of the genotyping error rate. When the number of loci is limiting, our approach maximizes the number of correct assignments by accounting for the frequencies of shared alleles. Comparisons with exclusion and likelihood-based methods on an empirical salmon dataset revealed that our Bayesian method had the highest ratio of correct to incorrect assignments. Availability: Our program SOLOMON is available as an R package from the CRAN website. SOLOMON comes with a fully functional graphical user interface, requiring no user knowledge about the R programming environment. In addition to performing Bayesian parentage analysis, SOLOMON includes Mendelian exclusion and a priori power analysis modules. Further information and user support can be found at https://sites.google.com/site/parent-agemethods/. Contact: christim@science.oregonstate.edu Supplementary information: Supplementary data are available at Bioinformatics online.

URL<Go to ISI>://WOS:000316270400008
DOI10.1093/bioinformatics/btt039