TitleAging signaling pathways and circadian clock-dependent metabolic derangements
Publication TypeJournal Article
Year of Publication2013
AuthorsTevy, MF, Giebultowicz, J, Pincus, Z, Mazzoccoli, G, Vinciguerra, M
JournalTrends in Endocrinology and Metabolism
Volume24
Pagination229-237
Type of ArticleJournal Article
ISSN1043-2760
Abstract

The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

URL<Go to ISI>://WOS:000319243500003
DOI10.1016/j.tem.2012.12.002